| Expression pattern: |
UP |
| Associated gene: |
LASP1, METTL3 |
| Associated microRNA: |
miR-1184 |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, tumor formation and radioresistance; inhibits apoptosis. |
| Molecular mechanism: |
METTL3-mediated m6A modification of circ_0124554 promotes CRC progression and radioresistance by inducing LASP1 expression through interaction with miR-1184. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes); m6A modification (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; MeRIP / MeRIP-seq; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential target to improve radiosensitivity of CRC. |
| Description: |
circ_0124554 is upregulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion, tumor growth and radioresistance while suppressing apoptosis. Mechanistically, METTL3-mediated m6A modification increases circ_0124554, which acts through the miR-1184/LASP1 axis to drive malignant phenotypes and resistance to radiation. |
| Confidence score: |
0.8005 |