circRNA basic information
circBase ID: hsa_circ_0028861
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr12:120636656-120636803:-
Genomic location(hg38): chr12:120198853-120199000:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: HBV-derived hepatocellular cancer
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: diagnostic biomarker for HBV-derived HCC; may influence HCC progression
Molecular mechanism: bioinformatics prediction suggests a circRNA-miRNA regulatory mechanism affecting tumor-related signaling pathways
Biological pathway or process:

PI3K/AKT (other); PI3K/AKT/mTOR (other); VEGF/VEGFR (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

novel diagnostic biomarker for discriminating HCC from chronic HBV and cirrhosis; useful for detecting small, early-stage and AFP-negative tumors; combination with AFP improves diagnostic performance
Description:

Serum exosomal hsa_circ_0028861 is down-regulated in HBV-derived HCC versus chronic HBV/cirrhosis and serves as a diagnostic biomarker, including for small, early-stage, and AFP-negative HCC. Bioinformatics analyses suggest it may regulate target miRNAs and thereby affect tumor-related pathways (e.g., integrin, VEGF, PI3K/Akt, mTOR) potentially influencing HCC progression.
Confidence score:

0.5047
Other information
Title:

The Potential of Serum Exosomal hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34367259
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fgene.2021.703205/full#supplementary-material
Code availability: -