| Expression pattern: |
UP |
| Associated gene: |
HOXA9 |
| Associated microRNA: |
miR-491-5p |
| Biological function: |
circ-SFMBT2 promotes proliferation, migration and invasion of AML cells and inhibits apoptosis; silencing circ-SFMBT2 inhibits proliferation, migration and invasion and promotes apoptosis. |
| Molecular mechanism: |
circ-SFMBT2 acts as a miR-491-5p sponge and regulates the miR-491-5p/HOXA9 axis in AML cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circ-SFMBT2 expression is associated with decreased overall survival in children with AML. |
| Description: |
circ-SFMBT2 is up-regulated in pediatric AML bone marrow samples and AML cell lines, and high expression is associated with poor overall survival. Functionally, circ-SFMBT2 promotes AML cell proliferation, migration and invasion and suppresses apoptosis, at least partly by sponging miR-491-5p and regulating HOXA9. |
| Confidence score: |
0.7962 |