| Expression pattern: |
DN |
| Associated gene: |
FOXO4, SMAD2, p-SMAD2, MMP9, MMP2 |
| Associated microRNA: |
miR-17-3p |
| Biological function: |
Circ_0084443 suppresses TGF-beta1-induced keratinocyte migration and downregulates migration-associated MMP9/MMP2 expression, thereby inhibiting wound healing-related keratinocyte motility. |
| Molecular mechanism: |
Circ_0084443 acts as a ceRNA sponge for miR-17-3p, positively regulates FOXO4 expression, and inactivates the canonical TGFbeta/SMAD2 signaling pathway in TGF-beta1-induced keratinocytes. |
| Biological pathway or process: |
migration (inhibits); TGF-beta/SMAD (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
Circ_0084443 may have application potential in wound-healing-related diseases and may provide a possible intervention strategy for cutaneous wound therapy. |
| Description: |
Circ_0084443 is downregulated in TGF-beta1-induced human keratinocytes and is mainly cytoplasmic. Functionally, circ_0084443 inhibits TGF-beta1-induced keratinocyte migration by sponging miR-17-3p, thereby increasing FOXO4 expression and suppressing the canonical TGFbeta/SMAD2 signaling pathway. The study suggests circ_0084443 as a potential intervention target for wound-healing-related diseases. |
| Confidence score: |
0.6528 |