| Expression pattern: |
UP |
| Associated gene: |
FZD3 |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
May serve as a potential diagnostic and progression-related biomarker for colorectal cancer; its upregulation is associated with CRC tissues and cell lines. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network involving circRNA_0001573/miR-382-5p/FZD3, with possible involvement of the Wnt signaling pathway in CRC. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May provide a potential diagnosis and predictive marker for diagnosis and progression of colorectal cancer. |
| Description: |
hsa_circ_0001573 is upregulated in colorectal cancer tissues and CRC cell lines, with expression verified by qRT-PCR and resistance to RNase R digestion. The study proposes a circRNA_0001573/miR-382-5p/FZD3 regulatory axis as a potential mechanism related to CRC progression and suggests circRNA_0001573 as a potential diagnostic and progression biomarker. |
| Confidence score: |
0.5135 |