| Expression pattern: |
DN |
| Associated gene: |
AGO2, FUS, LIN28A, PTB, EIF4A3 |
| Associated microRNA: |
miR-203, miR-1272, miR-1283, miR-31, miR-638, miR-496, miR-485-3p, miR-766, miR-876-3p |
| Biological function: |
Suppresses proliferation and migration of gastric cancer cells (knockdown promotes proliferation and migration). |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism; predicted binding to RBPs (AGO2, FUS, LIN28A, PTB, EIF4A3); predicted protein-coding potential based on IRES/ORF/m6A features. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; IF (Immunofluorescence); Wound Healing Assay; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased circPVRL3 is associated with higher TNM stage; low circPVRL3 expression is associated with shorter survival; ROC AUC 0.7626 for distinguishing GC from adjacent nontumorous tissues; circPVRL3 is an independent prognostic indicator for overall survival. |
| Description: |
circPVRL3 is down-regulated in gastric cancer tissues and cell lines. Functionally, circPVRL3 acts as a tumor-suppressive circRNA: its knockdown increases proliferation and migration. Mechanistically, it is mainly cytoplasmic and is predicted to sponge multiple miRNAs and interact with RBPs, with additional predicted protein-coding potential. |
| Confidence score: |
0.8196 |