circRNA basic information
circBase ID: hsa_circ_0005909
Name: -
Synonym: circ_0005909
Host Gene: -
Genomic location(hg19): chr1:180793888-180794480:+
Genomic location(hg38): chr1:180824752-180825344:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: Osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; adjacent non-cancerous bone tissues; plasma
Cell lines:

MG63; HOS; 143B; U2OS; hFOB1.19; H293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGA1, ERK, Akt, PI3K
Associated microRNA: miR-338-3p
Biological function: promotes cell proliferation
Molecular mechanism: ceRNA sponging of miR-338-3p leading to increased HMGA1 and activation of MAPK-ERK and PI3K-Akt signaling
Biological pathway or process:

proliferation (promotes); ERK (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In osteosarcoma, circ_0005909 (hsa_circ_0005909) is up-regulated and promotes OS cell proliferation. It functions as a ceRNA that sponges miR-338-3p to increase HMGA1 expression, thereby activating ERK/MAPK and PI3K/AKT signaling.
Confidence score:

0.7759
Other information
Title:

CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis.

Journal: Cancer management and research
Published: 2021
PubMed ID: 33536787
Study type:

combined biological and clinical study
Data availability: -
Code availability: -