| Expression pattern: |
DN |
| Associated gene: |
HOXD10 |
| Associated microRNA: |
miR‐520g |
| Biological function: |
inhibits proliferation, migration, invasion and metastasis of CRC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0000317 sponges miR-520g to modulate HOXD10 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
may be a promising diagnostic biomarker and a therapeutic target for CRC |
| Description: |
circ_0000317 is down-regulated in colorectal cancer tissues and cell lines and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits CRC cell proliferation, migration, invasion, and in vivo metastasis by sponging miR-520g to upregulate HOXD10. |
| Confidence score: |
0.697 |