| Expression pattern: |
UP |
| Associated gene: |
AMOTL1 / angiomotin-like 1 |
| Associated microRNA: |
miR-338-5p |
| Biological function: |
Promotes aggressive phenotypes of CRC cells, including proliferation, migration and cell cycle progression, while inhibiting apoptosis; facilitates CRC progression. |
| Molecular mechanism: |
hsa_circ_0001278 functions through a ceRNA mechanism by sponging miR-338-5p and regulating AMOTL1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Wound Healing Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
May serve as a novel target for CRC treatment; high expression was associated with CRC occurrence, gender, and tumor location. |
| Description: |
hsa_circ_0001278 is upregulated in colorectal cancer tissues and cell lines and appears to act as an oncogenic circRNA. It promotes CRC cell proliferation, migration and cell cycle progression while inhibiting apoptosis, mainly through the hsa_circ_0001278/miR-338-5p/AMOTL1 ceRNA axis. The study suggests hsa_circ_0001278 may be a potential therapeutic target for CRC. |
| Confidence score: |
0.7028 |