circRNA basic information
circBase ID: hsa_circ_0022587
Name: hsa_circ_SLC3A2
Synonym: circSLC3A2
Host Gene: SLC3A2
Genomic location(hg19): chr11:62650379-62653080:+
Genomic location(hg38): chr11:62882907-62885608:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues
Cell lines:

HepG2; LO2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PPM1F, Ago2
Associated microRNA: miR-490-3p
Biological function: promotes cell proliferation and invasion
Molecular mechanism: acts as a miRNA sponge for miR-490-3p to regulate PPM1F expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; RT-qPCR; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

high circSLC3A2 expression was associated with poorer survival in patients with HCC
Description:

circSLC3A2 (hsa_circ_0022587), derived from SLC3A2, is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation and invasion by acting as a sponge for miR-490-3p, thereby increasing PPM1F expression, and high circSLC3A2 correlates with poorer patient survival.
Confidence score:

0.8416
Other information
Title:

CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.

Journal: Molecular cancer
Published: 2018
PubMed ID: 30470261
Study type:

combined biological and clinical study
Data availability: TCGA-Liver Cancer RNA sequencing database (https://genome-cancer.ucsc.edu)
Code availability: -