| Expression pattern: |
UP |
| Associated gene: |
CPSF6 |
| Associated microRNA: |
miR-548b-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, stemness and xenograft tumor growth; silencing circ_0000673 reduces these malignant phenotypes. |
| Molecular mechanism: |
circ_0000673 functions as a ceRNA by sponging miR-548b-3p to upregulate CPSF6 expression in CRC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); stemness (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000673 expression was associated with poorer overall survival, and ROC curve analysis indicated clinical prognostic significance and potential as a diagnostic biomarker. |
| Description: |
circ_0000673 is up-regulated in colorectal cancer tissues and cells and acts as a tumor-promoting circRNA. Mechanistically, it sponges miR-548b-3p to increase CPSF6 expression, thereby promoting CRC cell proliferation, migration, invasion, stemness and xenograft tumor growth. Clinically, high circ_0000673 expression is associated with poorer overall survival and may have prognostic or diagnostic biomarker value. |
| Confidence score: |
0.8201 |