circRNA basic information
circBase ID: hsa_circ_0001766
Name: hsa_circ_PDIA4
Synonym: -
Host Gene: PDIA4
Genomic location(hg19): chr7:148716083-148718239:-
Genomic location(hg38): chr7:149018991-149021147:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; normal oral mucosal tissues
Cell lines:

SCC9; SCC25; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: miR-877-3p
Biological function: promotes OSCC cell proliferation
Molecular mechanism: ceRNA mechanism: hsa_circ_0001766 sponges miR-877-3p to upregulate VEGFA
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; CCK8; Colony Formation Assay; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0001766 (from PDIA4) is upregulated in OSCC tissues and OSCC cell lines. Functionally, its knockdown suppresses OSCC cell proliferation. Mechanistically, it likely acts as a ceRNA that sponges miR-877-3p to increase VEGFA expression, and miR-877-3p inhibition rescues the effects of hsa_circ_0001766 knockdown.
Confidence score:

0.7754
Other information
Title:

Expression Profile of Circular RNAs in Oral Squamous Cell Carcinoma.

Journal: Frontiers in oncology
Published: 2020
PubMed ID: 33330021
Study type:

combined biological and clinical study
Data availability: GSE131182
Code availability: -