circRNA basic information
circBase ID: hsa_circ_0001806
Name: -
Synonym: circ_0001806
Host Gene: -
Genomic location(hg19): chr8:68018139-68028357:+
Genomic location(hg38): chr8:67105904-67116122:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent tissues
Cell lines:

A549; H1975; H1650; HCC827; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOVA2
Associated microRNA: miR-1182
Biological function: promotes proliferation, migration and invasion of NSCLC cells
Molecular mechanism: ceRNA-like mechanism: circ_0001806 binds (sponges) miR-1182, relieving miR-1182-mediated repression and indirectly increasing NOVA2 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circ_0001806 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration, and invasion. Mechanistically, it localizes mainly to the cytoplasm and binds miR-1182, thereby relieving miR-1182 repression and indirectly increasing NOVA2 expression.
Confidence score:

0.6829
Other information
Title:

Circ_0001806 Promotes the Proliferation, Migration and Invasion of NSCLC Cells Through miR-1182/NOVA2 Axis.

Journal: Cancer management and research
Published: 2021
PubMed ID: 33854376
Study type:

combined biological and clinical study
Data availability: GSE101684; GSE135918; available from the corresponding author upon request
Code availability: -