| Expression pattern: |
UP |
| Associated gene: |
HOXA1 |
| Associated microRNA: |
miR-198 |
| Biological function: |
Promotes prostate cancer progression, xenograft tumour growth, cell proliferation, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0074032 acts as a miR-198 sponge/decoy to elevate HOXA1 expression, thereby promoting prostate cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0074032 expression was associated with Gleason score, TNM stage, lymph node metastasis and shorter overall survival, indicating potential as a prognostic biomarker for PCa patients. |
| Description: |
hsa_circ_0074032/circ_0074032 is up-regulated in prostate cancer tissues and cell lines, and high expression is associated with shorter overall survival and adverse clinicopathological features. Functionally, it promotes PCa cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ_0074032 acts as a miR-198 sponge to increase HOXA1 expression, forming a circ_0074032/miR-198/HOXA1 regulatory axis. |
| Confidence score: |
0.8818 |