circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA11:120406118|12040782
Host Gene: hsa-miR-30b-5p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: silica-induced lung fibrosis
Species: human
Species details: human
Sample type: cell line
Sample type details: MRC-5 (human lung fibroblasts cell line) or THP-1 (human leukemia monocyte cell line)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: NLRP3
Associated microRNA: hsa-miR-30b-5p
Biological function: circRNA11:120406118|12040782 was shown to regulate silica-stimulated macrophage pyroptosis through circRNA11:120406118|12040782/miR-30b-5p/NLRP3 network. And this macrophage-derived cirRNA could promote the activation of fibroblasts.
Molecular mechanism: overexpressing miR-30b-5p, the crucial component of circRNA11:120406118|12040782/miR-30b-5p/NLRP3 regulatory network, could inhibit pyroptosis and attenuate silica-induced lung inflammation and fibrosis in mice.
Survival: -
Supported No.:
 1
Description:

Our findings suggested that exosomal circRNA11:120406118|12040782 could aggravate NLRP3-mediated macrophages pyroptosis through sponging miR-30b-5p in silicosis development, which provide an experimental basis and shed light on the early diagnosis and treatment of silicosis.
Other information
Title:

The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.

Journal: Int Immunopharmacol
Published: 2022/12/1
PubMed ID: 36450208