circRNA basic information
circBase ID: hsa_circ_0000375
Name: hsa_circ_IFFO1
Synonym: circ_0000375
Host Gene: IFFO1
Genomic location(hg19): chr12:6657590-6657991:-
Genomic location(hg38): chr12:6548424-6548825:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent normal mammary tissues; normal mammary tissues
Cell lines:

MDA-MB-231; BT-549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: LPL, DGAT2, ADIPOQ
Associated microRNA: miR-7706
Biological function: Overexpression of hsa_circ_0000375 restrains proliferation, migration and invasion abilities of breast cancer cells, indicating an anti-oncogene role.
Molecular mechanism: hsa_circ_0000375 acts through a ceRNA-like miRNA sponge mechanism involving miR-7706 and may target LPL, DGAT2 and ADIPOQ.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay
Clinical significance:

May provide potential therapeutic targets for breast cancer.
Description:

hsa_circ_0000375 is significantly down-regulated in breast cancer tissues. Its overexpression suppresses breast cancer cell proliferation, migration and invasion, at least partly through sponging miR-7706 and potentially affecting LPL, DGAT2 and ADIPOQ.
Confidence score:

0.5923
Other information
Title:

The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer.

Journal: Molecular biology reports
Published: 2023
PubMed ID: 37904009
Study type:

combined biological and clinical study
Data availability: GSE101123; TCGA
Code availability: -