| Expression pattern: |
UP |
| Associated gene: |
CCND1 / Cyclin D1 |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, colony-forming ability, cell cycle progression, and tumor growth in vivo. |
| Molecular mechanism: |
hsa_circ_0079557 acts as a molecular sponge for miR-502-5p and up-regulates CCND1 expression, thereby promoting CRC cell proliferation. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May provide a new target for diagnosing and treating CRC. |
| Description: |
hsa_circ_0079557 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, colony formation, cell cycle progression, and xenograft tumor growth by sponging miR-502-5p and increasing CCND1 protein expression. The proposed hsa_circ_0079557/miR-502-5p/CCND1 pathway may represent a potential diagnostic or therapeutic target in CRC. |
| Confidence score: |
0.8175 |