| Expression pattern: |
UP |
| Associated gene: |
TSPAN14 |
| Associated microRNA: |
miR-637 |
| Biological function: |
Serves as a promising and reliable diagnostic biomarker for lung cancer; may regulate downstream genes by regulating miR-637 and affect tumor migration. |
| Molecular mechanism: |
Predicted circHIPK3/miR-637 axis with a predicted downstream target gene TSPAN14; possible ceRNA-related regulation affecting cell migration and Notch signaling-related processes. |
| Biological pathway or process: |
ceRNA regulation (other); migration (other); Notch (other); lipid metabolism (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
EV-derived circHIPK3 can serve as a promising biomarker for lung cancer patient diagnosis, with ROC AUC 0.897 for distinguishing lung cancer from healthy controls. |
| Description: |
EV-derived circHIPK3 is significantly up-regulated in plasma extracellular vesicles from lung cancer patients and shows diagnostic potential with an AUC of 0.897. The study predicts that circHIPK3 may interact with miR-637 and potentially influence downstream TSPAN14-related processes, including migration-associated pathways, although the downstream mRNA axis requires further experimental exploration. |
| Confidence score: |
0.5047 |