| Expression pattern: |
UP |
| Associated gene: |
ribosomes, EJC, RBM8A, EIF4A3, RPS6, eEF-1A |
| Associated microRNA: |
- |
| Biological function: |
circSDHAF2 promotes colorectal cancer tumorigenesis, tumor growth and anchorage-independent tumorsphere formation; knockdown suppresses tumorsphere number and size and delays xenograft tumor development. |
| Molecular mechanism: |
EJC-mediated cap-independent translation of coding circSDHAF2 produces SDHAF2mh5, a modified SDHAF2 isoform; EJC components bridge circSDHAF2 to ribosomes, and RBM8A depletion reduces circSDHAF2-ribosome association and translation. |
| Biological pathway or process: |
proliferation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
circSDHAF2 was elevated in colorectal cancer tumorous tissues compared with adjacent nontumor tissues, suggesting its expression may benefit colorectal cancer development. |
| Description: |
circSDHAF2 is an up-regulated coding circRNA in colorectal cancer tumor tissues. It undergoes EJC-mediated cap-independent translation to produce SDHAF2mh5, and its coding activity promotes tumorsphere formation and xenograft tumor growth. Knockdown of circSDHAF2 suppresses anchorage-independent growth and delays tumor formation in mice. |
| Confidence score: |
0.8191 |