circRNA basic information
circBase ID: hsa_circ_0067985
Name: hsa_circ_FNDC3B
Synonym: -
Host Gene: FNDC3B
Genomic location(hg19): chr3:171944660-171969331:+
Genomic location(hg38): chr3:172226870-172251541:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100116
MONDO name: Middle East respiratory syndrome
Disease details: Middle East respiratory syndrome coronavirus
Disease DO ID:
 0080642
Disease MeSH ID:
 -
Disease NCIt ID:
 C128424
Disease ICD11 ID:
 1840423014
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Calu-3; HFL
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Ago2, MAP3K9, MYO15B, SPOCK1
Associated microRNA: -
Biological function: promotes MERS-CoV replication; positively regulates representative target mRNA expression
Molecular mechanism: acts as a miRNA sponge (ceRNA) with predicted Ago2 binding sites, thereby regulating target mRNAs
Biological pathway or process:

ceRNA regulation (other); MAPK (other); viral replication (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; divergent primers PCR; RT-qPCR; Sanger Sequencing; Bioinformatics Analysis; Transfection
Clinical significance:

-
Description:

hsa_circ_0067985 (circFNDC3B), derived from FNDC3B, is up-regulated upon MERS-CoV infection and functions as a predicted ceRNA/miRNA sponge with Ago2 binding sites. Its knockdown decreases representative target mRNAs (e.g., MAP3K9, MYO15B, SPOCK1) and suppresses MERS-CoV replication, while overexpression enhances viral replication.
Confidence score:

0.5761
Other information
Title:

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.

Journal: Emerging microbes & infections
Published: 2020
PubMed ID: 32223537
Study type:

biological research
Data availability: GSE139516
Code availability: -