| Expression pattern: |
UP |
| Associated gene: |
TGFBR2 |
| Associated microRNA: |
miR-940 |
| Biological function: |
circ_0001226 promotes LPS-induced BEAS-2B cell injury by suppressing cell proliferation and enhancing apoptosis and inflammation; circ_0001226 knockdown ameliorates LPS-induced growth inhibition and inflammatory injury. |
| Molecular mechanism: |
circ_0001226 acts as a molecular sponge for miR-940 and thereby regulates TGFBR2 expression in LPS-induced BEAS-2B cells. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); inflammation (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot |
| Clinical significance: |
circ_0001226 may be a marker for clinical diagnosis and treatment and has potential clinical applications in diagnosis, prognostication, and treatment. |
| Description: |
hsa_circ_0001226 is up-regulated in serum from SA-ALI patients and in LPS-induced BEAS-2B cells. It promotes SA-ALI-related cell injury by sponging miR-940 to up-regulate TGFBR2, thereby enhancing proliferation inhibition, apoptosis, and inflammatory cytokine production. Knockdown of circ_0001226 alleviates LPS-induced BEAS-2B dysfunction, suggesting potential diagnostic and therapeutic relevance. |
| Confidence score: |
0.7591 |