| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circLPAR1 is reduced in GC tissue and plasma exosomes, is closely related to GC progression, and may serve as a marker for auxiliary diagnosis, prognosis evaluation, postoperative monitoring, and adverse outcome assessment. |
| Molecular mechanism: |
The study did not define a specific molecular mechanism; plasma exosomal circLPAR1 was evaluated as an exosomal circulating biomarker, and the authors state that the specific mechanism needs further basic research. |
| Biological pathway or process: |
metastasis (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
Plasma exosomal circLPAR1 has diagnostic value for GC, is associated with clinicopathological features, and high expression is associated with significantly better prognostic survival; low expression is a risk factor for adverse prognosis. |
| Description: |
This study shows that circLPAR1/hsa_circ_0087960 is down-regulated in gastric cancer tissues and plasma exosomes. Plasma exosomal circLPAR1 has diagnostic value, correlates with clinicopathological progression features, increases after surgery, and high expression is associated with better survival. The work supports circLPAR1 as a non-invasive exosomal biomarker for GC diagnosis and prognosis, but does not experimentally define its molecular mechanism. |
| Confidence score: |
0.4992 |