| Expression pattern: |
UP |
| Associated gene: |
HK2 |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
Promotes OSCC cell proliferation and glycolysis; tumour-promoting factor; circMDM2 knockdown represses tumour growth in vivo. |
| Molecular mechanism: |
circMDM2 acts as a miRNA sponge for miR-532-3p, thereby increasing HK2 expression (ceRNA axis circMDM2/miR-532-3p/HK2). |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circMDM2 was overexpressed in OSCC tissue and cells, and high expression served as a poor prognostic factor for OSCC patients. |
| Description: |
circMDM2 is up-regulated in OSCC tissues and cell lines and promotes OSCC cell proliferation and glycolysis. It acts as a ceRNA by sponging miR-532-3p to upregulate HK2, and high circMDM2 expression is associated with poor patient survival. |
| Confidence score: |
0.8419 |