| Expression pattern: |
DN |
| Associated gene: |
AATK, STK39, p38 |
| Associated microRNA: |
miR-196a-3p |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration, and invasion; inhibits tumorigenesis; triggers apoptosis |
| Molecular mechanism: |
Acts as a miRNA sponge binding miR-196a-3p to upregulate AATK, leading to inactivation of the STK39/p38 signaling pathway |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); MAPK (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Luciferase Reporter Assay; RNA Pull-Down; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Co-IP; Western Blot; Survival Analysis; Microarray |
| Clinical significance: |
circPTK2 may serve as a novel therapeutic target for gastric cancer |
| Description: |
circPTK2 (hsa_circ_0005273), derived from PTK2, is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-196a-3p to relieve repression of AATK, thereby inhibiting malignant behaviors (proliferation/migration/invasion), promoting apoptosis, and suppressing xenograft tumor growth, with downstream involvement of the STK39/p38 pathway. |
| Confidence score: |
0.8861 |