circRNA basic information
circBase ID: hsa_circ_0008309
Name: hsa_circ_CUL3
Synonym: circ_006740
Host Gene: CUL3
Genomic location(hg19): chr2:225400244-225422573:-
Genomic location(hg38): chr2:224535527-224557856:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

oral squamous cell carcinoma tissue; adjacent normal tissue
Cell lines:

SCC9; SCC15; SCC25; CAL27; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May be implicated in oncogenesis and development of OSCC; downregulation related to pathological differentiation.
Molecular mechanism: Predicted circRNA/miRNA interaction (miRNA sponge) by StarBase/TargetScan; no specific miRNAs reported in text.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Downregulation of circ_006740 was related to pathological differentiation.
Description:

circ_006740 (hsa_circ_0008309, from CUL3) is significantly down-regulated in OSCC tissues and OSCC cell lines. Its downregulation is associated with pathological differentiation, and it is bioinformatically predicted to bind miRNAs consistent with a miRNA-sponge role.
Confidence score:

0.585
Other information
Title:

Circular RNA Expression in Oral Squamous Cell Carcinoma.

Journal: Frontiers in oncology
Published: 2018
PubMed ID: 30349810
Study type:

combined biological and clinical study
Data availability: -
Code availability: -