circRNA basic information
circBase ID: -
Name: hsa_circ_Sirt1
Synonym: Circular RNA Sirt1
Host Gene: Sirt1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0008383
MONDO name: rheumatoid arthritis
Disease details: Rheumatoid arthritis
Disease DO ID:
7148
Disease MeSH ID:
D001172
Disease NCIt ID:
C2884
Disease ICD11 ID:
576319925
Disease OMIM ID:
180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

fibroblast-like synovium cells

Cell lines:

MH7A

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: Sirt1
Associated microRNA: miR-132
Biological function: Inhibits proliferation, induces apoptosis, suppresses pro-inflammatory cytokine production, decreases MMP levels, attenuates inflammation and oxidative stress in RA-FLS MH7A cells.
Molecular mechanism: circ-Sirt1 functions as a miR-132 sponge to regulate Sirt1 expression, activates Sirt1 signaling, inhibits NF-jB signaling, and activates the Nrf2/HO-1 pathway.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); inflammation (inhibits); NF-kappaB (inhibits); ceRNA regulation (promotes); other pathway/process (promotes)

Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; ELISA; Western Blot; IF (Immunofluorescence); Luciferase Reporter Assay; Bioinformatics Analysis

Clinical significance:

circ-Sirt1 may be useful as a therapeutic target for the treatment of RA.

Description:

circ-Sirt1 is down-regulated in RA-FLS MH7A cells compared with normal FLS. Its overexpression suppresses MH7A proliferation, promotes apoptosis, reduces IL-1b, IL-6, TNF-a, MMP-1 and MMP-3, and ameliorates inflammation through a miR-132/Sirt1-related mechanism involving inhibition of NF-jB signaling and activation of Nrf2/HO-1 signaling. The study proposes circ-Sirt1 as a potential therapeutic target for RA.

Confidence score:

0.6441

Other information
Title:

Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes.

Journal: Autoimmunity
Published: 2021
PubMed ID: 34431434
Study type:

biological research

Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -