| Expression pattern: |
UP |
| Associated gene: |
CTNNBIP1, beta-catenin, TCF3, TCF4, LEF1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes PTC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
circRNA_102171 binds CTNNBIP1 and blocks CTNNBIP1 interaction with the beta-catenin/TCF/LEF complex, thereby activating Wnt/beta-catenin signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; Western Blot |
| Clinical significance: |
- |
| Description: |
circRNA_102171 is up-regulated in papillary thyroid cancer tissues/cell lines and functions as an oncogenic circRNA by promoting proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it binds CTNNBIP1 and disrupts CTNNBIP1-beta-catenin binding, enhancing beta-catenin association with TCF/LEF and activating Wnt/beta-catenin signaling. |
| Confidence score: |
0.7458 |