| Expression pattern: |
DN |
| Associated gene: |
SCAI |
| Associated microRNA: |
miR-767-5p |
| Biological function: |
Re-expressing circ_0052611 suppressed BRCA cell migration, invasion, Warburg Effect-related glycolysis, and tumor growth in vivo, and promoted apoptosis. |
| Molecular mechanism: |
circ_0052611 acts as a ceRNA sponge for miR-767-5p to modulate SCAI expression. |
| Biological pathway or process: |
glycolysis (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
potential clinical application as biomarkers and therapeutic targets for BRCA treatment |
| Description: |
hsa_circ_0052611/circ_0052611 is a NOL10-derived human circRNA downregulated in BRCA tissues and cells. It functions as a tumor-suppressive circRNA by sponging miR-767-5p to upregulate SCAI, thereby inhibiting Warburg Effect-related glycolysis, migration, invasion, EMT-associated marker changes, and xenograft tumor growth while promoting apoptosis. The study proposes the circ_0052611/miR-767-5p/SCAI ceRNA axis as a potential biomarker and therapeutic target for BRCA. |
| Confidence score: |
0.8396 |