| Expression pattern: |
UP |
| Associated gene: |
Tetraspanin-3 (TSPAN3), TSPAN3 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
circ_103809 promotes PC cell growth viability, clonogenic ability, migration, invasion, metastasis, and malignant progression; silencing circ_103809 restrains these malignant phenotypes. |
| Molecular mechanism: |
circ_103809 acts through a ceRNA-like mechanism by directly binding miR-197-3p, thereby upregulating TSPAN3 and promoting malignant progression of PC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
circ_103809 is proposed as a probable biomarker and therapeutic target for PC. |
| Description: |
circ_103809 is up-regulated in pancreatic cancer tissues and cell lines and functions as a promoter of malignant phenotypes. Mechanistically, it directly binds miR-197-3p and upregulates TSPAN3, thereby enhancing PC cell proliferation, colony formation, migration, invasion, and metastasis-related behavior. The study proposes the circ_103809/miR-197-3p/TSPAN3 axis as a potential biomarker and therapeutic target for PC. |
| Confidence score: |
0.6815 |