circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_008901
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005387
MONDO name: primary ovarian failure
Disease details: premature ovarian insufficiency
Disease DO ID:
 5426
Disease MeSH ID:
 D016649
Disease NCIt ID:
 C113352
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; peripheral venous blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN, AKT, STAT, P13K, CREB, FNIP, STX6, LMAN2, ADSS, STYK1, EIF2S1, CABP4, MAP7D1, NUFIP2, SDC4, FKBP15
Associated microRNA: hsa-miR-548c-3p, hsa-miR-924, hsa-miR-4677-5p, hsa-miR-6786-3p, hsa-miR-7974
Biological function: May serve as an early diagnostic biomarker for POI and may affect follicle growth and development, ovarian granulosa cell differentiation and proliferation, oocyte maturation, inflammatory aging, and glucose metabolism.
Molecular mechanism: Predicted ceRNA mechanism as a miRNA sponge regulating miRNA-associated mRNAs and signaling pathways such as PI3K-AKT.
Biological pathway or process:

PI3K/AKT (other); ceRNA regulation (other); proliferation (other); apoptosis (other); inflammation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Good diagnostic value for POI; AUC = 0.8445; potential biomarker for early diagnosis of POI.
Description:

hsa_circRNA_008901 was significantly downregulated in plasma from POI patients and showed diagnostic potential with an AUC of 0.8445. Bioinformatics analysis suggested it may act as a miRNA sponge for five predicted miRNAs and may influence PI3K-AKT-related pathways, follicle development, granulosa cell proliferation/differentiation, inflammation, and glucose metabolism.
Confidence score:

0.5047
Other information
Title:

Circular RNA as new serum metabolic biomarkers in patients with premature ovarian insufficiency.

Journal: Archives of gynecology and obstetrics
Published: 2023
PubMed ID: 37740794
Study type:

combined clinical and bioinformatics study
Data availability: GSE222497
Code availability: -