| Expression pattern: |
UP |
| Associated gene: |
IPMK |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes proliferation, inhibits apoptosis, inflammation and oxidative stress; mediates resveratrol-induced protection against LPS-induced HK2 cell injury |
| Molecular mechanism: |
ceRNA mechanism; circ_0074371 sponges miR-145-5p to positively regulate IPMK |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); inflammation (inhibits); oxidative stress (inhibits); cell cycle (promotes); drug resistance (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; ELISA; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circ_0074371 was upregulated in AKI patients; resveratrol may alleviate sepsis-induced AKI by regulating circ_0074371-related pathway |
| Description: |
circ_0074371 is upregulated in septic AKI and acts as a pro-injury circRNA in LPS-stimulated HK2 cells. It sponges miR-145-5p to increase IPMK, thereby promoting apoptosis, inflammation, oxidative stress and inhibiting cell proliferation; resveratrol alleviates injury partly by suppressing this circ_0074371/miR-145-5p/IPMK axis. |
| Confidence score: |
0.7223 |