| Expression pattern: |
UP |
| Associated gene: |
DNMT3A |
| Associated microRNA: |
miR-7-5p |
| Biological function: |
Circ_0005785 promotes CRC cell proliferation, invasion, angiogenesis, EMT and tumor growth, and suppresses apoptosis. |
| Molecular mechanism: |
Circ_0005785 acts as a ceRNA by sponging miR-7-5p to increase DNMT3A expression, thereby aggravating CRC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); EMT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_0005785 expression was associated with poor overall survival in CRC patients. |
| Description: |
Circ_0005785 is up-regulated in CRC tissues and cell lines, and high expression is associated with poor overall survival. Functionally, circ_0005785 promotes CRC proliferation, invasion, angiogenesis, EMT and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-7-5p to increase DNMT3A expression, forming a circ_0005785/miR-7-5p/DNMT3A regulatory axis. |
| Confidence score: |
0.7892 |