| Expression pattern: |
UP |
| Associated gene: |
IGF1R, Ago2 |
| Associated microRNA: |
miR-141-5p |
| Biological function: |
promotes proliferation, migration, tumor growth and metastasis in TNBC |
| Molecular mechanism: |
circGNB1 acts as a ceRNA to sponge miR-141-5p and upregulate IGF1R |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High expression of circGNB1 was associated with worse clinical features and survival outcomes; high expression of circGNB1 was an independent risk factor for TNBC patients |
| Description: |
circGNB1 (hsa_circ_0009362), derived from GNB1, is up-regulated in TNBC and mainly localized in the cytoplasm. It promotes TNBC proliferation, migration and in vivo tumor growth/metastasis by sponging miR-141-5p and relieving repression of IGF1R (circGNB1/miR-141-5p/IGF1R ceRNA axis). High circGNB1 expression associates with worse clinicopathologic features and poor OS/DFS, serving as an independent prognostic risk factor. |
| Confidence score: |
0.8557 |