| Expression pattern: |
UP |
| Associated gene: |
PAK2, Ago2 |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes proliferation, migration, invasion and angiogenesis; inhibits apoptosis; promotes tumor growth/tumorigenesis |
| Molecular mechanism: |
ceRNA mechanism: circ_0008717 sponges miR-1287-5p to elevate PAK2; exosomal packaging/transfer |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RNase R Treatment; Transfection; MTT; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
high circ_0008717 expression was linked with tumor size and advanced TNM stages |
| Description: |
circ_0008717 (circABCB10) is up-regulated in NSCLC tissues, cells, and patient serum-derived exosomes. It promotes NSCLC malignant phenotypes and tumor growth by acting as a ceRNA to sponge miR-1287-5p, thereby increasing PAK2 expression, and it is packaged into exosomes enabling extracellular transfer. |
| Confidence score: |
0.8035 |