| Expression pattern: |
UP |
| Associated gene: |
IGFBP3, AGO2 |
| Associated microRNA: |
miR-133a-5p |
| Biological function: |
promotes proliferation, invasion, migration, EMT, tumor growth and metastasis in nasopharyngeal carcinoma |
| Molecular mechanism: |
ceRNA mechanism: circ-0046263 sponges miR-133a-5p to upregulate IGFBP3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes); TGF-beta/SMAD (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
circ-0046263 expression was positively correlated with the clinical pathological stage of NPC and significantly associated with lymph node metastasis and distant metastasis; proposed as a prognostic factor |
| Description: |
circ-0046263 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, EMT, and metastasis). It mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-133a-5p to increase IGFBP3 expression, thereby driving NPC progression. |
| Confidence score: |
0.856 |