circRNA basic information
circBase ID: hsa_circ_0127664
Name: hsa_circ_KCNN2
Synonym: hsa_circKCNN2_003
Host Gene: KCNN2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

HGG tissues; LGG tissues; adjacent normal tissues / adjacent normal brain tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: DLGAP2
Associated microRNA: hsa-miR-3945, hsa-miR-99b-3p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponge (ceRNA) interactions; predicted RBPs/m6A features
Biological pathway or process:

ceRNA regulation (other); m6A modification (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value in distinguishing HGG from LGG (ROC AUC 0.8044).
Description:

hsa_circ_0127664 is down-regulated in HGG compared with LGG and has diagnostic potential by ROC analysis. The study predicts a circRNA-miRNA-mRNA network (e.g., via hsa-miR-99b-3p and DLGAP2) and reports relatively high predicted m6A modification, without functional experiments.
Confidence score:

0.6556
Other information
Title:

Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.

Journal: Aging
Published: 2020
PubMed ID: 33323543
Study type:

combined biological and clinical study
Data availability: -
Code availability: -