| Expression pattern: |
UP |
| Associated gene: |
AKT, mTOR, phosphorylated AKT, phosphorylated mTOR |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration, and invasion of PAAD cells; silencing circPGAM1 impairs proliferation, migration, and invasion. |
| Molecular mechanism: |
circPGAM1 activates the AKT/mTOR signaling pathway, increasing p-AKT/AKT and p-mTOR/mTOR levels; AKT inhibitor AZD5363 reverses circPGAM1-induced pathway activation and cell migration/invasion. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circPGAM1 was overexpressed in PAAD and associated with poor prognosis; high circPGAM1 expression was linked to lower overall and disease-free survival and may predict PAAD prognosis. |
| Description: |
circPGAM1 is up-regulated in pancreatic adenocarcinoma and is associated with poor overall and disease-free survival. Functionally, circPGAM1 promotes PAAD cell proliferation, migration, and invasion. Mechanistically, it activates the AKT/mTOR signaling pathway, and AKT inhibition with AZD5363 reverses circPGAM1-induced pathway activation and metastatic phenotypes. |
| Confidence score: |
0.5732 |