circRNA basic information
circBase ID: hsa_circ_0020123
Name: hsa_circ_PDZD8
Synonym: circ_0020123
Host Gene: PDZD8
Genomic location(hg19): chr10:119042605-119049859:-
Genomic location(hg38): chr10:117283094-117290348:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000831
MONDO name: thrombotic disease
Disease details: deep vein thrombosis
Disease DO ID:
 0060903
Disease MeSH ID:
 D013927
Disease NCIt ID:
 C26891
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; venous blood
Cell lines:

HUVECs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circ_0020123 inhibits HUVEC proliferation, angiogenesis, and migration, and promotes apoptosis, oxidative stress, inflammation, and thrombosis-related factor release in the DVT-related endothelial injury model.
Molecular mechanism: circ_0020123 participates in ox-LDL-induced HUVEC injury by regulating endothelial cell proliferation, angiogenesis, migration, apoptosis, oxidative stress, inflammatory responses, and thrombosis-related factors; no specific miRNA, protein, or signaling axis was identified.
Biological pathway or process:

proliferation (inhibits); angiogenesis (inhibits); migration (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Tube Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; ELISA
Clinical significance:

Increased circ_0020123 is an independent risk factor for DVT in pregnant women and circ_0020123 is proposed as a new circRNA biomarker for DVT in pregnant women.
Description:

circ_0020123 is up-regulated in serum from pregnant women with DVT and in ox-LDL-treated HUVECs. The study identifies increased circ_0020123 as an independent risk factor and new biomarker for DVT in pregnant women, and functionally shows that circ_0020123 aggravates endothelial cell injury by inhibiting proliferation, angiogenesis, and migration while promoting apoptosis, oxidative stress, inflammation, and thrombosis-related factors.
Confidence score:

0.7223
Other information
Title:

Circ_0020123, a New Circular RNA Biomarker for Deep Vein Thrombosis in Pregnant Women.

Journal: Clinical laboratory
Published: 2023
PubMed ID: 37702682
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: -