circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD12
Synonym: circANKRD12
Host Gene: ANKRD12
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

human bile; bile EV samples
Cell lines:

RBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes proliferation, migration and invasion abilities of cholangiocarcinoma cell RBE; potential diagnostic marker and potential therapeutic target for malignant cancer.
Molecular mechanism: Underlying mechanisms require further investigation.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential marker used to distinguish malignant cancers from benign biliary diseases; may represent a potential therapeutic target for malignant cancer.
Description:

circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved.
Confidence score:

0.6616
Other information
Title:

Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis.

Journal: Carcinogenesis
Published: 2023
PubMed ID: 37696683
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -