| Expression pattern: |
UP |
| Associated gene: |
Rac1 |
| Associated microRNA: |
miR-1915-3p |
| Biological function: |
Promotes GC cell viability, growth, invasion, migration, cell cycle progression, and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ-ABCB10 acts as a ceRNA by sponging miR-1915-3p to upregulate Rac1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-ABCB10 expression is associated with poorer overall survival in GC patients; circ-ABCB10 might be a potential target for GC diagnosis and treatment. |
| Description: |
circ-ABCB10 is upregulated in gastric cancer tissues and cell lines and is associated with poorer overall survival. Functionally, circ-ABCB10 promotes GC cell growth, migration, invasion, cell cycle progression, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts through a circ-ABCB10/miR-1915-3p/Rac1 ceRNA axis and may represent a diagnostic or therapeutic target for GC. |
| Confidence score: |
0.7986 |