| Expression pattern: |
UP |
| Associated gene: |
HMGB1, PI3K, AKT, Ago2 |
| Associated microRNA: |
miR‐193a |
| Biological function: |
Promotes breast cancer cell proliferation, migration, and invasion; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-193a to increase HMGB1 expression and activate HMGB1/PI3K/AKT signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; MTT; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Upregulation of CirCHIPK3 predicted a worse prognosis in BC patients; high CirCHIPK3 expression group had poorer survival. |
| Description: |
CirCHIPK3 is up-regulated in breast cancer and is associated with worse overall survival. Functionally, it promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-193a to increase HMGB1 and activate the HMGB1/PI3K/AKT pathway. |
| Confidence score: |
0.8008 |