| Expression pattern: |
UP |
| Associated gene: |
PEX5, Ago2 |
| Associated microRNA: |
miR-513a-5p |
| Biological function: |
Promotes NSCLC malignant phenotypes (proliferation, colony formation, migration, invasion), glycolysis, EMT, Wnt/beta-catenin pathway activation, tumor growth and lung metastasis. |
| Molecular mechanism: |
Acts as a miRNA sponge to competitively bind miR-513a-5p, thereby increasing PEX5 expression and promoting malignant behaviors and Wnt/beta-catenin activation. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); glycolysis (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Survival Analysis |
| Clinical significance: |
Upregulated in NSCLC patients and associated with poorer survival outcomes; potential biomarker/prognostic indicator. |
| Description: |
circSEC61A1 is upregulated in NSCLC and functions as an oncogenic circRNA. It sponges miR-513a-5p to increase PEX5 expression, thereby promoting NSCLC cell malignant behaviors, glycolysis, EMT, and Wnt/beta-catenin pathway activation, and enhancing tumor growth and metastasis. |
| Confidence score: |
0.8491 |