circRNA basic information
circBase ID: hsa_circ_0079586
Name: hsa_circ_IGF2BP3
Synonym: circRNA_0079586
Host Gene: IGF2BP3
Genomic location(hg19): chr7:23353140-23383472:-
Genomic location(hg38): chr7:23313521-23343853:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005291
MONDO name: brain aneurysm
Disease details: intracranial aneurysm
Disease DO ID:
 10941
Disease MeSH ID:
 D002532
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

intracranial aneurysm tissue; endothelial cells
Cell lines:

HUVEC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MPO
Associated microRNA: miR-183-5p
Biological function: Activates MPO expression and is involved in the pathogenesis of intracranial aneurysms rupture.
Molecular mechanism: ceRNA-like regulation where miR-183-5p suppresses circRNA-0079586 and MPO; circRNA_0079586 negatively correlates with miR-183-5p and positively correlates with MPO.
Biological pathway or process:

ceRNA regulation (promotes); inflammation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Luciferase Reporter Assay; Transfection; Clinical Sample Validation; Bioinformatics Analysis; Western Blot
Clinical significance:

-
Description:

circRNA_0079586 is up-regulated in endothelial cells from ruptured intracranial aneurysms and in turbulent-flow-treated HUVECs. It participates in an MPO-modulating axis (circRNA_0079586/miR-183-5p/MPO) supported by luciferase assays and gain/loss-of-function transfections, where higher circRNA_0079586 associates with lower miR-183-5p and higher MPO.
Confidence score:

0.6432
Other information
Title:

CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.

Journal: Scientific reports
Published: 2021
PubMed ID: 34611229
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -