circRNA basic information
circBase ID: hsa_circ_0082846
Name: hsa_circ_EZH2
Synonym: circ-EZH2
Host Gene: EZH2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; adjacent nontumor tissues
Cell lines:

U87MG; U251; U118; LN229; NHA
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DDAH1, CBX3
Associated microRNA: miR-1265
Biological function: Circ-EZH2 functions as an oncogene in glioma cells, promoting cell proliferation, colony formation, migration and invasion while attenuating apoptosis.
Molecular mechanism: Circ-EZH2 acts as a ceRNA by sponging miR-1265, thereby relieving miR-1265-mediated suppression of DDAH1 and CBX3.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

Circ-EZH2 is upregulated in glioma tissues and cell lines and acts as an oncogenic circRNA. It promotes glioma cell proliferation, migration and invasion and inhibits apoptosis through a ceRNA mechanism involving miR-1265-mediated regulation of DDAH1 and CBX3.
Confidence score:

0.6536
Other information
Title:

Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity.

Journal: Gene
Published: 2020
PubMed ID: 31669648
Study type:

combined biological and clinical study
Data availability: -
Code availability: -