| Expression pattern: |
UP |
| Associated gene: |
GPX4, ACSL4 |
| Associated microRNA: |
- |
| Biological function: |
Alleviates CSE-induced BEAS-2B cell ferroptosis and injury; reduces apoptosis, ROS and Fe2+ levels; reverses MMP decline. |
| Molecular mechanism: |
Mechanism not investigated in depth; functional evidence from siRNA knockdown suggests circRNA contributes to ferroptosis regulation, associated with GPX4/ACSL4 changes. |
| Biological pathway or process: |
ferroptosis (inhibits); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis; Transfection; Flow Cytometry（Non-apoptosis/cycle）; Western Blot |
| Clinical significance: |
potential therapeutic target of CSE related lung injury |
| Description: |
In CSE-treated BEAS-2B cells, hsa_circ_0025843 is up-regulated. siRNA knockdown of hsa_circ_0025843 alleviates CSE-induced ferroptosis-associated injury, accompanied by increased GPX4 and decreased ACSL4, suggesting a protective effect when suppressed. |
| Confidence score: |
0.4852 |