circRNA basic information
circBase ID: hsa_circ_0015758
Name: hsa_circ_CFH
Synonym: -
Host Gene: CFH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tumor samples; adjacent normal tissues
Cell lines:

NHAs; U87; A172; U251; TJ905; U373
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT1
Associated microRNA: miR-149
Biological function: promotes glioma progression; increases cell proliferation and colony formation
Molecular mechanism: ceRNA mechanism: circ-CFH sponges miR-149 to regulate AKT1
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes); PI3K/AKT (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

Circ-CFH expression was correlated with tumor grade.
Description:

circ-CFH (has_circ_0015758) is up-regulated in glioma tissues and glioma cell lines and promotes glioma growth. It acts as a miR-149 sponge to derepress AKT1, enhancing proliferative capacity in vitro and tumor growth in xenografts.
Confidence score:

0.6916
Other information
Title:

Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2018
PubMed ID: 30111766
Study type:

combined biological and clinical study
Data availability: -
Code availability: -