| Expression pattern: |
UP |
| Associated gene: |
PFN2, HIF-1a, HK2, LDH-A |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
Promotes breast cancer cell proliferation, glycolysis, colony formation, xenograft tumor growth and irradiation resistance; circABCB10 silencing inhibits these malignant phenotypes and improves irradiation sensitivity. |
| Molecular mechanism: |
circABCB10 acts as a sponge for miR-223-3p to upregulate PFN2, thereby promoting glycolytic metabolism and irradiation resistance in breast cancer. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Potential novel direction for radiotherapy of breast cancer by targeting circABCB10-mediated glycolysis and irradiation sensitivity. |
| Description: |
circABCB10 is up-regulated in breast cancer tissues and cells. It promotes breast cancer progression, glycolysis and irradiation resistance by sponging miR-223-3p and increasing PFN2 expression; circABCB10 knockdown suppresses malignant phenotypes and enhances irradiation sensitivity. |
| Confidence score: |
0.6521 |