| Expression pattern: |
UP |
| Associated gene: |
TRIP13 |
| Associated microRNA: |
miR-615-5p |
| Biological function: |
Promotes proliferation, migration, and invasion of prostate cancer cells; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-615-5p, thereby upregulating TRIP13 (miR-615-5p targets TRIP13 3'-UTR). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Potential candidate for targeted therapy of PCa. |
| Description: |
circRNA_100146 is up-regulated in prostate cancer cells and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, and xenograft tumor growth by sponging miR-615-5p and thereby relieving miR-615-5p-mediated repression of TRIP13. |
| Confidence score: |
0.7014 |