| Expression pattern: |
DN |
| Associated gene: |
ALX4, Ago2 |
| Associated microRNA: |
miR-1204 |
| Biological function: |
inhibits proliferation, migration, invasion, EMT, and metastasis of HCC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0000098 sponges miR-1204 to upregulate ALX4 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; H&E Staining; Clinical Sample Validation |
| Clinical significance: |
its underexpression was associated with larger tumor size of HCC patients |
| Description: |
circ_0000098 (circSLC30A7) is down-regulated in HCC tissues/cells and acts as a tumor-suppressive circRNA. It functions mainly in the cytoplasm as a ceRNA that sponges miR-1204, thereby relieving repression of ALX4 and inhibiting proliferation, migration, invasion, EMT, and lung metastasis. |
| Confidence score: |
0.8206 |