| Expression pattern: |
DN |
| Associated gene: |
PHLDA1 |
| Associated microRNA: |
miR-101-3p.1, miR-101 |
| Biological function: |
Suppresses gastric cancer cell proliferation (cell survival) and metastasis (migration/invasion). |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-101-3p.1 (miR-101), thereby regulating PHLDA1 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Clinical Sample Validation |
| Clinical significance: |
Circ_0027599 was suggested as a potential diagnostic marker and was negatively associated with aggressive clinicopathological features (tumor size, depth of invasion, lymph node/distant metastasis, TNM stage). |
| Description: |
In gastric cancer, circ_0027599 is down-regulated in tumors and blood and functions as a tumor suppressor by inhibiting proliferation and metastasis-related behaviors. Mechanistically, it sponges miR-101-3p.1 (miR-101) to relieve repression of PHLDA1, forming a circ_0027599/miR-101/PHLDA1 regulatory axis with potential diagnostic relevance. |
| Confidence score: |
0.6777 |