| Expression pattern: |
UP |
| Associated gene: |
WNT5A, AGO2 |
| Associated microRNA: |
miR-578 |
| Biological function: |
promotes OS cell proliferation, colony formation, invasion, motility, tumor growth, lung metastasis and liver metastasis |
| Molecular mechanism: |
circTNPO1 acts as a miR-578 sponge to upregulate WNT5A expression and promote OS progression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
high expression was correlated with clinicopathological characteristics of OS patients, such as tumor size and TNM stage; targeting circTNPO1 could be a potential strategy for inhibiting OS progression |
| Description: |
circTNPO1 (hsa_circ_0072932), derived from TNPO1, is up-regulated in osteosarcoma tissues and cells and mainly localized in the cytoplasm. It promotes OS proliferation, invasion, migration, tumor growth and metastasis by sponging miR-578 and thereby upregulating WNT5A. High circTNPO1 expression is associated with tumor size and TNM stage, suggesting potential therapeutic relevance. |
| Confidence score: |
0.8772 |