circRNA basic information
circBase ID: hsa_circ_0088212
Name: hsa_circ_PAPPA
Synonym: circ_0088212
Host Gene: PAPPA
Genomic location(hg19): chr9:118949432-119164600:+
Genomic location(hg38): chr9:116187153-116402321:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissue; nearby normal tissue; OS tumoral and adjacent normal tissues
Cell lines:

SW1353; Saos-2; HOS; hFOB1.19
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: FKBP1A, Bcl-2, Bax, Ago2
Associated microRNA: miR-576-5p
Biological function: circ_0088212 inhibits OS cell proliferation and migration, promotes apoptosis, and suppresses tumor growth in vivo.
Molecular mechanism: circ_0088212 acts as a ceRNA sponge for miR-576-5p and positively modulates FKBP1A expression, thereby suppressing OS progression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other); metastasis (inhibits)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

low circ_0088212 expression was associated with a higher stage, higher grade, and metastasis
Description:

circ_0088212 is downregulated in osteosarcoma tissues and cell lines. Its overexpression suppresses OS proliferation, migration, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0088212 functions as a ceRNA for miR-576-5p to positively regulate FKBP1A expression, forming a circ_0088212/miR-576-5p/FKBP1A tumor-suppressive axis.
Confidence score:

0.7785
Other information
Title:

Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression.

Journal: Annals of clinical and laboratory science
Published: 2023
PubMed ID: 37625838
Study type:

combined biological and clinical study
Data availability: GSE96964; GSE12865
Code availability: -