| Expression pattern: |
DN |
| Associated gene: |
AGO2, MMP1, MMP17 |
| Associated microRNA: |
miR-558 |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; inhibits Taxol resistance; increases Taxol sensitivity |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-558 (AGO2-associated), affecting downstream targets MMP1 and MMP17 and thereby suppressing malignant phenotypes and Taxol resistance. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); chemoresistance (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circ_0030998 expression resulted in a higher survival rate of lung cancer patients; high expression was negatively related to invasion, distal metastasis and TNM stage. |
| Description: |
hsa_circ_0030998 (circ_0030998), derived from LAMP1 exon 3, is down-regulated in lung cancer tissues/cells and in Taxol-resistant cells. It functions mainly in the cytoplasm as a miR-558 sponge (AGO2-associated), thereby suppressing lung cancer cell proliferation, migration, invasion and reducing Taxol resistance, and its higher expression is associated with better patient survival. |
| Confidence score: |
0.8708 |