| Expression pattern: |
DN |
| Associated gene: |
LARP4, Ago2 |
| Associated microRNA: |
miR-513b-5p |
| Biological function: |
Suppresses cell proliferation, migration and invasion; promotes apoptosis in ovarian cancer cells |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-513b-5p and indirectly upregulates its host gene/target LARP4 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_LARP4 is down-regulated in ovarian cancer cell lines and functions as a tumor suppressor. It mainly localizes in the cytoplasm and acts as a ceRNA that sponges miR-513b-5p, thereby relieving repression of LARP4 and inhibiting proliferation/migration/invasion while promoting apoptosis. |
| Confidence score: |
0.8081 |