| Expression pattern: |
UP |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Diagnostic and prognostic biomarker; high expression predicts shorter progression-free survival, cancer-specific survival, and overall survival in ccRCC after nephrectomy. |
| Molecular mechanism: |
Bioinformatically predicted binding to RNA-binding proteins and miRNAs (potential miRNA sponge), not experimentally validated. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circEHD2 levels were an independent predictor of shortened progression-free survival, cancer-specific survival, and overall survival in ccRCC patients undergoing nephrectomy; moderate diagnostic accuracy (AUC = 0.757). |
| Description: |
circEHD2 is upregulated in ccRCC versus normal renal tissue. High circEHD2 levels independently predict worse survival outcomes (PFS/CSS/OS) after nephrectomy, supporting its prognostic (and moderate diagnostic) biomarker value. |
| Confidence score: |
0.6759 |