| Expression pattern: |
DN |
| Associated gene: |
GOT2 |
| Associated microRNA: |
- |
| Biological function: |
Inhibits tumor cell growth; promotes GOT2 expression. |
| Molecular mechanism: |
Proposed ceRNA/miRNA sponge mechanism regulating GOT2 and gluconeogenesis-related genes. |
| Biological pathway or process: |
gluconeogenesis (promotes); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; Transfection; RT-qPCR; CCK8; Western Blot |
| Clinical significance: |
Might be associated with prognosis of HCC patients (inferred indirectly via target gene GOT2 survival associations). |
| Description: |
hsa_circ_0002130 is a downregulated ceRNA-network circRNA in HCC and, when overexpressed in HCC cell lines, suppresses cell proliferation while increasing GOT2 RNA and protein expression. The study proposes that hsa_circ_0002130 may act as a miRNA sponge to upregulate GOT2 and affect gluconeogenesis-related programs. |
| Confidence score: |
0.4852 |